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Medicinal Chemical Facilities

Medicinal Chemistry Shared Resource

Institution The Ohio State University
Contact Name Ching-Shih Chen, Director
Contact Email
Main Website Visit Main Website
Hit Selection and Optimization Services - Analog Synthesis
Other Hit Selection and Optimization Services
Lead Selection and Optimization Services - Custom-Designed Analog Synthesis
Other Lead Selection and Optimization Services
Scale-up Synthetic Capabilities for Hits/Analogs
Can the facility support in silico screening? No
Is the facility open to projects not affiliated with host institution? No
Is data collected in this facility publicly available? Varies by project
Additional Comments Consultation and general medicinal chemistry service The MCSR will consult with OSUCCC – James investigators regarding the chemical stability, commercial sources and purity of chemical agents available from commercial sources. It also will conduct nuclear magnetic resonance spectrometry and mass spectrometric analyses when the identity and/or purity of a chemical agent is in question. For pharmaceutical agents obtained in tablet form, the MCSR will help with extraction and purification to obtain the active pharmaceutical ingredient (API) with high purity. Custom synthesis The MCSR will provide custom synthesis of agents that are not available from commercial sources. Chemists of the MCSR will consult with interested investigators regarding the synthetic feasibility of the requested agents, and will carry out the synthesis if deemed feasible. Lead optimization The MCSR provides strategies to help OSUCCC – James investigators conduct structural optimization of existing lead agents.